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In symptomatic women, a preliminary careful clinical examination and imaging investigation (ultrasound and/or mammograms) is necessary before a breast FNA. Ultrasound examination alone is recommended for young and pregnant women. For older symptomatic or asymptomatic women, bilateral mammograms are needed before any breast FNA and can be followed by complementary mammographic work up and/or ultrasound examination if necessary. There is no need to stop medication (e.g. aspirin or anticoagulant medication) before a breast FNA.
It is important for the referring doctor to provide all the relevant information (clinical findings, nature and duration of the symptoms, exact location of the lesion, personal and family history for breast cancer, presence of breast implant(s), anticoagulant medication, use of HRT, previous radiotherapy/chemotherapy) on the request form for the specialist doctor who will perform the breast FNA and for the cytologist who will interpret the results.
There are no absolute contraindications for breast FNA.
Needle phobia, previous vasovagal episode, or inability to cooperate (due to dementia, physical disability or stroke) can make the procedure technically difficult or impossible.
Breast FNA is more difficult in the presence of breast implant. There is a minimal risk of damaging the implant, depending of the location of the breast lesion, but there is no contraindication for a breast FNA. Very small or very large breasts may make breast FNA technically impossible.
Anticoagulant medications (aspirin, warfarin or PIavix) are not contraindicated for a Breast FNA, but the specialist doctor who will perform the test needs to be aware of any of anticoagulant medication as there is more risk of bleeding and more compression will be required after the FNA to avoid a haematoma.
A bruise can appear after the procedure, especially if the patient is taking anticoagulant medication (aspirin, warfarin, PIavix). Minimal bleeding and bruising and rarely a haematoma may happen during or after the procedure. Good compression after the procedure is usually enough to avoid any severe bleeding.
There is minimal risk of infection. Breast pain after FNA is uncommon and can be relieved by simple analgesic (paracetamol or Panadol, no aspirin).
Pneumothorax (perforation of the lung cover causing collapse of the lung) is extremely rare.
Breast implant perforation can happen but is a rare complication of a breast FNA.
Epithelium displacement and tumour cell dissemination along the needle tract may occur after any needle biopsy but are more common with larger needle biopsy (core) than with FNA. However the significance and implication of this rare complication is not actually known.
Inconclusive or non-diagnostic breast FNA, false positive and false negative breast FNA can happen and are more common with a breast FNA than with a larger core biopsy.
Breast FNA can be inconclusive, non-diagnostic or false negative for sampling error, inadequate specimen or because of the nature of the lesion (fibrotic lesion, micro-calcifications).
Distinguishing between ductal carcinoma in situ (DCIS) and invasive carcinoma is not possible on cytological examination. Cytological results need to be accurately correlated with the imaging and clinical findings (“triple test”).
A reference book: Breast fine needle aspiration cytology and core biopsy: a guide for practice:
Page last modified on 29/3/2017.
RANZCR® is not aware that any person intends to act or rely upon the opinions, advices or information contained in this publication or of the manner in which it might be possible to do so. It issues no invitation to any person to act or rely upon such opinions, advices or information or any of them and it accepts no responsibility for any of them.
RANZCR® intends by this statement to exclude liability for any such opinions, advices or information. The content of this publication is not intended as a substitute for medical advice. It is designed to support, not replace, the relationship that exists between a patient and his/her doctor. Some of the tests and procedures included in this publication may not be available at all radiology providers.
RANZCR® recommends that any specific questions regarding any procedure be discussed with a person's family doctor or medical specialist. Whilst every effort is made to ensure the accuracy of the information contained in this publication, RANZCR®, its Board, officers and employees assume no responsibility for its content, use, or interpretation. Each person should rely on their own inquires before making decisions that touch their own interests.