Computed Tomography (CT)
What is computed tomography? Computed tomography (CT) is a way of using X-rays to take pictures or images in very…Read more
An octreotide scan is a form of somatostatin receptor imaging used to detect neuroendocrine tumours. These tumours, which arise from neuroendocrine hormone secreting cells, are characterised by an overexpression of somatostatin receptors.
The scan uses an isotope of indium, Indium-111, which is bound to pentetreotide to form 111In-pentetreotide, a radiopharmaceutical with a somatostatin analogue that binds to somatostatin receptors. The radiopharmaceutical is actively taken up by the overexpressed somatostatin receptors on neuroendocrine tumours (predominantly type 2 and 5).
Identifying a primary neuroendocrine tumour in the appropriate clinical setting, preoperative staging, restaging and assessment of treatment response.
Examples of tumours that have high overexpression of somatostatin receptors include, but are not limited to:
This study may not be suitable for pregnant women due to the low radiation risk to the both developing foetus and the mother. The benefit versus risk should be discussed with the nuclear medicine specialist.
Given that there is a small amount of radioactivity released for a while after the test, women who are breast-feeding may need to make special preparations after the test to stop breast-feeding for a short time. Similarly, close contact with young children should be avoided for a short time (see below).
The doctor should contact the hospital or radiology practice and check the scanner bed limits if their patient is morbidly obese.
There are no adverse affects from an octreotide scan. The amount of radiation exposure is quite safe and should not result in any short- or long-term hazardous effects.
111In-pentetreotide scan is eliminated from the body predominantly via the kidneys. Patients should be well hydrated before and after the scan. The biological half-life is approximately 6 hours.
If the scan was deemed medically necessary in pregnant and/or breast-feeding patients, hydration is crucial. The patient can express breast milk before the scan to use on the days of the scan. After the scan, milk should be discarded for the next 48 hours. The patient should minimise close contact with the baby and children under the age of 5 years for the next 24 hours. Patients should discuss this with their referring doctor or the nuclear medicine practice where they will have the test. See Nuclear Medicine for further information about the precautions to take with nuclear medicine studies for breast-feeding patients and those in close contact with children.
Other functional imaging includes 68Ga DOTA-Octreotate PET-CT scan and 123I/124I MIBG scan. PET imaging can be particularly useful in aggressive, rapidly-growing tumours that may not be seen on octreotide scanning.
CT and MRI can better delineate the anatomical relationships of any identifiable tumour.
Page last modified on 31/8/2018.
RANZCR® is not aware that any person intends to act or rely upon the opinions, advices or information contained in this publication or of the manner in which it might be possible to do so. It issues no invitation to any person to act or rely upon such opinions, advices or information or any of them and it accepts no responsibility for any of them.
RANZCR® intends by this statement to exclude liability for any such opinions, advices or information. The content of this publication is not intended as a substitute for medical advice. It is designed to support, not replace, the relationship that exists between a patient and his/her doctor. Some of the tests and procedures included in this publication may not be available at all radiology providers.
RANZCR® recommends that any specific questions regarding any procedure be discussed with a person's family doctor or medical specialist. Whilst every effort is made to ensure the accuracy of the information contained in this publication, RANZCR®, its Board, officers and employees assume no responsibility for its content, use, or interpretation. Each person should rely on their own inquires before making decisions that touch their own interests.